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Germ-free Mice (GF Mice) / Germ-free Animal
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Contents
Mostly mice, born and reared in sterile environments from which no microbiota can be cultured
Germ-free (GF) mice are an important model system for understanding the impact of gut microbes on development and function of the nervous system
Germ-free animals are animals kept in isolators in the absence of living microorganisms
However, the sterile state in itself is not fatal
Germ-free animals possess a reduced number of immune cells within their intestinal [lamina propria](brain://QhjO8KmUqE6DhUKNk8bLCQ/LaminaPro…
References (Sources)
- Cultured microbes represent a substantial fraction of the human and mouse gut microbiota.
- Deciphering interactions between the gut microbiota and the immune system via microbial cultivation and minimal microbiomes
- Development and maintenance of the gut-associated lymphoid tissue (GALT): the roles of enteric bacteria and viruses
- Dissecting the Interplay Between Intestinal Microbiota and Host Immunity in Health and Disease: Lessons Learned from Germfree and Gnotobiotic Animal Models
- Standardised animal models of host microbial mutualism
- The enhancing effect of the microbial flora on macrophage function and the immune response. A study in germfree mice
- The germfree animal in nutritional studies