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Alfa-synuclein aggregation is a key pathological feature of Parkinson’s disease (PD). This means that the clumping together of alfa-synuclein proteins is a significant indicator of the disease. Interestingly, this aggregation does not only occur in the areas of the brain traditionally associated with PD, such as the substantia nigra, but is also found in other regions outside of these areas, known as extranigral areas. This is particularly evident even in the early stages of Parkinson’s disease. Specifically, the aggregation can be observed in the dorsal motor nucleus of the [vagus nerve](brain://kKCOIcDMPkGD5SoAwnEfqg/ParasympatheticNervous…