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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Adiposity / Obesity & Butyrate / Butyric acid

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Feeding the obese mice with butyrate could activate the vagus nerve, which suppresses the appetite-related hormones’ release and then reduces the weight of mice
Chambers et al. 2015a Proc Nutr Soc 74: 328-36

Butyrate activates intestinal gluconeogenesis through the intestine-brain circuit , promoting glucose control and metabolic benefits reflected by body weight
De Vadder et al. 2014 Cell 156(1–2): 84-96

[Butyr…

References (Sources)

Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms
Lin et al. 2012 PloS one 7(4): e35240
Control of appetite and energy intake by SCFA: what are the potential underlying mechanisms?
Chambers et al. 2015a Proc Nutr Soc 74: 328-36
Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits
De Vadder et al. 2014 Cell 156(1–2): 84-96
The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon
Donohoe et al. 2011 Cell Metab 13(5): 517-526

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5/25/2026

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Adiposity / Obesity & Butyrate / Butyric acid

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