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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Chenodeoxycholic Acid (CDCA)

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Chenodeoxycholic Acid (CDCA) is the strongest FXR agonist with an EC50 value of about 10–20 µM
Li & Chiang 2020 Hepatobiliary Surg. Nutr. 9: 152-169

Chenodeoxycholic Acid (CDCA) also enhances production of Alcohol Dehydrogenase 1 (ADH1), enhancing alcohol breakdown
Woodhouse et al. 2018 Aliment Pharmacol Ther. 47: 192-202

Chenodeoxycholic Acid (CDCA) Inhibits Germination
Britton & Young 2014

References (Sources)

Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic liver disease
Li & Chiang 2020 Hepatobiliary Surg. Nutr. 9: 152-169
Review
Chenodeoxycholate is an inhibitor of Clostridium difficile spore germination
Sorg & Sonenshein 2009 J Bacteriol 191: 1115-7
Review article: the gut microbiome as a therapeutic target in the pathogenesis and treatment of chronic liver disease
Woodhouse et al. 2018 Aliment Pharmacol Ther. 47: 192-202
Review
Role of the Intestinal Microbiota in Resistance to Colonization by Clostridium difficile
Britton & Young 2014
Review

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5/29/2026

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Chenodeoxycholic acid - Wikipedia