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On the one hand, these neuropeptides (Substance P (SP) (SP), calcitonin gene-related peptide (CGRP), VIP) interact with immune cells to mediate neurogenic inflammation, intestinal contraction and mucus secretion, and is important for pathogen clearance
Zhu et al. 2022a Front. Cell Dev. Biol. 10: 906755
On the other hand, due to the similar structure to antibacterial peptides (AMP), neuropeptides act on the negatively charged cell membrane of bacteria, change the membrane structure through depolarization, produce physical pores, and play an antibacterial role (Ganz, 2003; Hansen et al., 2006).…