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Medical Research Finder

Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Toll-like receptor 2 (TLR-2) / Toll-like receptor 6 (TLR-6) heterodimer (TLR-2/TLR-6) / MYD88 / NFKB signaling pathway

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Toll-like receptor 2 (TLR-2) : Toll-like receptor 6 (TLR-6) heterodimer (TLR-2:TLR-6) : MYD88 : NFKB signaling pathway

The agonists Zymosan, Trypanosoma cruzi GIPLs, Glycolipids (GIPLs)) lead to dimerization (= TLR2 / TLR6 heterodimer). The two adapter molecules, TIR domain-containing adapter protein (TIRAP) and Myeloid Differentiation Primary Response 88 (MYD88) are activated. Receptor-associated MyD88 recruits [Interleukin-1 receptor-associated kinase 4 (IR…

Modulation of atherosclerosis in mice by Toll-like receptor 2
Mullick et al. 2005 J. Clin. Invest. 115: 3149-3156
Recognition and signaling by Toll-like receptors
West et al. 2006 Annu Rev Cell Dev Biol. 22: 409-37
Review
The role of Toll-like receptors and neuroinflammation in Parkinson’s disease
Heidari et al. 2022 Journal of Neuroinflammation 19: 135
Review
TLR2 looks at lipoproteins
Schenk et al. 2009 Immunity 31: 847-849
Ubiquitin signalling in the NF-κB pathway
Chen 2005 Nat. Cell. Biol. 7: 758-65

5/29/2026