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2-Phosphoglycerate / 2-Phosphoglyceric acid is an essential intermediate during glycolysis. 2-Phosphoglycerate is a three-carbon molecule with the chemical formula C3H7O7P. It contains a phosphate group bonded to the second carbon atom of glyceric acid. Due to the deprotonation of the phosphate group, the molecule is anionic at physiological pH.
2-Phosphoglycerate is formed from 3-phosphoglycerate by the action of the enzyme phosphoglycerate mutase (PGAM). This conversion is a crucial step in the glycolytic pathway:
3 phosphoglycerate → 2 phosphoglycerate
Following this, 2-phosphoglycerate is converted into phosphoenolpyruvate (PEP) by the enzyme [enolase](brain://9j61ySRoAE-WwwD-XUTU…