Lumazine synthase

Lumazine synthase is an enzyme that catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2) in plants, fungi, and many microorganisms, but not in animals or humans.
Persson et al. 1999 Protein Sci 8(11): 2355-65
Morgunova et al. 2007 J Biol Chem 282(23): 17231-41
Talukdar et al. 2012 J Org Chem 77(14): 6239-61

Lumazine synthase facilitates the condensation of specific substrates to produce 6,7-dimethyl-8-ribityllumazine, which is then converted to riboflavin by Riboflavin synthase. This pathway is essential for the survival and growth of many pathogens and plants, making the enzyme a potential target for antifungal o…