meRfi®-GM
TF (Thomsen-Friedenreich) antigen (Gal beta1-3 GalNAc alfa1-Ser/Thr)
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Contents
Key feature: Serine (Ser) / Threonine (Thr) + GalNAc + R
TF (Thomsen-Friedenreich) antigen (Gal beta1-3 GalNAc alfa1-Ser/Thr) is a Tn (GalNAc-O-Ser/Thr) antigen. Thomsen-Friedenreich (TF) antigen (ß-Gal-[1 → 3]-a-GalNAc- O -serine) is immunogenic in vivo and generates TF-specific Cytotoxic T cell (CTL)
Binding of sambucus nigra agglutinin (SNA) to serum TF-specific antibodies
see also:
Tn (GalNAc-O-Ser/Thr)
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References (Sources)
- Carbohydrate antigens as targets for active specific immunotherapy
- Designer Glycopeptides for Cytotoxic T Cell–based Elimination of Carcinomas
- Increased Avidity of the Sambucus nigra Lectin-Reactive Antibodies to the Thomsen-Friedenreich Antigen as a Potential Biomarker for Gastric Cancer
- Multifunctional nanobeacon for imaging Thomsen-Friedenreich antigen-associated colorectal cancer
- Thomsen-Friedenreich and Tn Antigens in Nipple Fluid: Carbohydrate Biomarkers for Breast Cancer Detection