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The prevalence of death from infection in unvaccinated humans is generally driven by age.
Abel & Casanova 2024 Immunity 57(7): 1457-1465
Bacterial infection occurs through Toll pathway and Immune deficiency (IMD) pathway
Royet et al. 2011
There is enormous individual clinical variation in the course of any infection
Casanova & Abel 2021a Annu. Rev. Pathol. 16: 23-50
No more than a dozen known microbes can kill more than 10% of infected individuals, even without medical prevention and treatment. Fewer than 100 microbes can kill more than 1% of infected individuals. Most of the remaining 3,000 known pathogens are less virulent and cause life-threatening disease in <1% of infected individuals. The obse…