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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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CD8aa

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The CD8aa form of CD8+, consisting of two alpha chains, is particularly significant in the context of intraepithelial lymphocytes (IELs).
Sujino et al. 2020 J Immunol 204 (1 Suppl.): 72.2

Thymic leukemia antigen (TL) is a nonclassical class I molecule abundantly expressed on intestinal epithelial cells.
Leishman et al. 2001 Science 294: 1936-1939

Thymic leukemia antigen (TL) preferentially binds the homotypic form CD8aa.
Leishman et al. 2001 Science 294: 1936-1939

This is a novel mechanism of lymphocyte regulation by …

References (Sources)

CD8aa TCRab intraepithelial lymphocytes MHC restriction (P1462)
Lambolez et al. 2013 J Immunol 190 (1 Suppl): 60.14
Glycolysis gene Hif1a negatively regulates the induction of intraepithelial CD4+CD8aa+ T cells
Sujino et al. 2020 J Immunol 204 (1 Suppl.): 72.2
T Cell Responses Modulated Through Interaction Between CD8αα and the Nonclassical MHC Class I Molecule, TL
Leishman et al. 2001 Science 294: 1936-1939

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