meRfi®-GM
The Digital Textbook on Gut Microbiota and Beyond
Food Allergy (FA) / Food Sensitivity & Immunoglobulin E (IgE)
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Food allergies can manifest in various forms, each distinguished by specific clinical symptoms. Among these, IgE-mediated food allergies (IgE-FA) are notable for their rapid onset, occurring within minutes to several hours after exposure to the allergen.
In IgE-mediated food allergy (IgE-FA), the body continuously produces food-specific Immunoglobulin E (IgE). These antibodies attach to the high-affinity IgE receptor, known as FcεRI, which is primarily located on tissue-resident mast cells and circulating basophils. When the allergen is ingested, the IgE antibodies recognize and bind to it, resulting in receptor crosslin…