Riboflavin synthase

Riboflavin synthase is an enzyme that catalyzes the final step in the biosynthesis of riboflavin (vitamin B2) by facilitating the transfer of a four-carbon fragment between two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione.

Riboflavin synthase is present in microorganisms and plants, but absent in animals, making it a target for antimicrobial drug development because humans must obtain riboflavin from their diet.
Fischer et al. 2003 BMC Biochem 4: 18
Serer et al. 2019 F…