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Cancer / Tumors & Exosomes
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Emerging evidence demonstrates that cancer-derived exosomes are enriched in immunosuppressive proteins (e.g., PD-L1)
Immune Suppression Has Been Hypothesized to Be Mediated by Exosomes from Cancer cells
A human in vitro model system shows that exosomes, a population of small membrane vesicles secreted by living tumor cells, contain and transfer tumor antigens to dendritic cells.
After mouse tumor exosome uptake, dendritic cells induce potent CD8+ T-cell-dependent antitumor effects on syngeneic and allogeneic established mouse tumors.
Wolfers et al., 2001 Nat Me…
References (Sources)
- Exosome Targeting of Tumor Antigens Expressed by Cancer Vaccines can lmprove Antigen lmmunogenicity and Therapeutic Efficacy
- Exosomes and Cancer: A Newly Described Suppression
- Exosomes as a Multicomponent Biomarker Platform in Cancer
- Extracellular and nuclear PD-L1 in modulating cancer immunotherapy
- Mechanisms underlying low-clinical responses to PD-1/PD-L1 blocking antibodies in immunotherapy of cancer: a key role of exosomal PD-L1Review
- Role of exosomal miR-21 in the tumor microenvironment and osteosarcoma tumorigenesis and progression
- Roles of exosomes in cancer chemotherapy resistance, progression, metastasis and immunity, and their clinical applicationsReview