meRfi®-GM
Neoantigens
Welcome to meRfi-GM!
meRfi-GM provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.
Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.
Start your free trial and transform your understanding of the gut microbiota today!
Navigation
Contents
These are a specific class of tumor antigens that arise from new (hence "neo") mutations in the tumor’s DNA. These mutations can result from genomic alterations, abnormal RNA splicing, or post-translational modifications, and they produce peptides that are unique to the tumor and absent from normal cells.
Because they are truly "non-self," the immune system is not tolerant to them, making them highly immunogenic and attractive targets for cancer immunotherapy
Xie et …
References (Sources)
- Antigen Spreading Contributes to MAGE Vaccination- Induced Regression of Melanoma Metastases
- Effect of sialic acid loss on dendritic cell maturation
- Isolation of Novel HLA-DR Restricted Potential Tumor-associated Antigens from the Melanoma Cell Line FM3
- Neoantigen: A New Breakthrough in Tumor Immunotherapy
- Neoantigens: promising targets for cancer therapy
- New Concepts in Tumor Antigens: Their Significance in Future Immunotherapys for TumorsReview
- Tumor-associated carbohydrates and immunomodulatory lectins as targets for cancer immunotherapy