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Acute inflammation changes the microvasculature, resulting in inflammatory exudate (fluids, proteins, and cells in the extravascular space)
An acute inflammation caused by infection or injury is the most familiar type of inflammation
Cardinal signs of acute inflammation are redness, swelling, heat, and pain
Inflammation can also be present in the absence of infection or tissue injury triggers
Inflammation is a deviation of a biological system from its“normal” homeostatic state in response to some perturbation
As compared with an organ-based classification, molecular classification better addresses pathophysiological commonalities across IMIDs that affect different organs but also accounts for substantial mechanistic differences among IMIDs that affect the same organ
Inflammation is associated with almost every human disease
Inflammation is a key determinant of many human diseases. It is mediated by vessel-lining endothelial cells. These cells critically orchestrate the inflammatory trafficking of leukocytes and the process of aging.
Acute inflammation can be caused by pathogenic bacteria. Invading pathogens induce the expansion of TH17 cells and ILC3. TH17 cell-associated cytokines attract neutrophils and trigger a pro-inflammatory response in order to clear the invading agent. Furthermore, IL-17A and IL-22 promote enterocyte proliferation and migration, thereby promoting mucosal healing. After clearance of the pathogen, the intestinal immune system returns to homeostasis
Inflammation - a Source of Cancers & Many Other Diseases
The incidence and prevalence of chronic inflammatory diseases have increased markedly since the end of the Second World War, in line with the pattern of increasing urbanization and industrialization
Inflammation defends the host against unwanted elements.
During inflammation costimulatory molecules such as CD80, CD86, and others (e.g., CD83) are upregulated as well as IL-2 production
During inflammation MHC molecules remain on the cell surface for at least several hours; during Inflammation the density of MHC molecules is upregulated
Inflammation has also been classified as Type 1 and Type 2 based on the type of cytokines and helper T cells (Th1 and Th2 ) involved
see also:
Carcinogenesis / Oncogenesis / Tumorigenesis
Inflammatory Responses / Inflammation