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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Regulatory T Cells (Tregs) & Short-Chain Fatty Acids (SCFAs)

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SCFAs increase number and function of colonic regulatory T (Treg ) cells
Arpaia et al. 2013 Nature 504: 451-455
Furusawa et al. 2013
Smith et al. 2013
Rooks & Garrett 2016 Nature Rev. Immunology 16: 341

Short-chain fatty acids (SCFAs) Promote Polarization of Naive T Cells toward Regulatory T Cells (Tregs)
Haghikia et al. 2015

SCFAs attenuate inﬂammatory diseases by accelerating regulatory T cell (Treg) development
Furusawa et al. 2013
Smith et al. 2013
Haghikia et al. 2015

Short-Chain Fatty Acids (SCFAs) were also found capa…

References (Sources)

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Furusawa et al. 2013
Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine
Haghikia et al. 2015
Gut microbiota, metabolites and host immunity
Rooks & Garrett 2016 Nature Rev. Immunology 16: 341
Review
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia et al. 2013 Nature 504: 451-455
Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway
Park et al. 2015a Mucosal Immunol. 8: 80-93
The gut microbiome in health and in disease
Shreiner et al. 2015 Curr. Opin. Gastroenterol. 31: 69-75
Review
The microbial metabolites, short chain fatty acids, regulate colonic Treg cell homeostasis
Smith et al. 2013

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Regulatory T Cells (Tregs) & Short-Chain Fatty Acids (SCFAs)

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