SAM domain and HD domain-containing protein 1 (SAMHD1)

In humans, SAMHD1 hydrolyzes deoxynucleotides triphosphates during HIV-1 infection.
Goldstone et al. 2011 Nature 480: 379-382

SAMHD1 depletes the pool of Deoxynucleoside triphosphate (dNTP) / Nucleotide.
Goldstone et al. 2011 Nature 480: 379-382
Tal et al. 2022 Nat. Microbiol. 7: 1200-1209