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The administration of IRT5 probiotics has been shown to down-regulate the level of pro-inflammatory cytokines in inflamed tissues. IRT5, which is a mixture of five probiotics, not only increases the levels of Treg and IL-10 in the superficial lymph nodes of EAE mice but also reduces the amount of Th17 and the secretion of IFN-gamma, Tumor Necrosis Factor alfa (TNF-alfa), and IL-17. IRT5 is provided by Korea Yakult Co. (Giheung, Korea), and the powder contains 1×10^8 cfu/g of each strain, consisting of Lactobacillus casei, Lactobacillus acidophilus, [Lactobacillus re…