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Diminished abundance of Short-Chain Fatty Acids (SCFAs) results in loss of Hypoxia and Barrier Integrity: Loss of cellular and luminal physiological hypoxia reduces HIF1 expression, resulting in the loss of tight junction and adhesion molecule expression and function. This allows bacterial translocation, triggering the innate immune response.
Microbial SCFA production is essential for gut integrity by regulating the luminal pH, mucus production, providing fuel for epithelial cells , and effects on muco…