meRfi®-GM
The Digital Textbook on Gut Microbiota and Beyond
Clostridioides (Clostridium) difficile
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Contents
General Information
- GeneBank Accessions: CP003939, CP010905
- Scientific Name: Clostridioides difficile
- Common Name: C. difficile
- Characteristics:
- Gram-positive
- Anaerobic
- Spore-forming
- Motile
Pathogenicity and Virulence
Clostridioides difficile is a bacterial pathogen that causes a range of clinical diseases, from mild to moderate diarrhea to more severe conditions such as pseudomembranous colitis and toxic megacolon (). The virulence of C. difficile is strain-dependent, with particularly virulent strains like the [Clostridioides (Clostridium) difficile Hypervirulent Clade 2(brain://KZitF6GUVUC14XOu8XP2nw/Cl…
References (Sources)
- Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota
- Clostridium difficile spore biology: sporulation, germination, and spore structural proteins
- Entry of spores into intestinal epithelial cells contributes to recurrence of Clostridioides difficile infection
- The regulatory network controlling spore formation in Clostridium difficile
- The role of toxin A and toxin B in Clostridium difficile infection
- The role of toxin A and toxin B in the virulence of Clostridium difficile
- Trends in US burden of Clostridioides difficile infection and outcomes