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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Clostridioides (Clostridium) difficile

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Contents

General Information

GeneBank Accessions: CP003939, CP010905

Scientific Name: Clostridioides difficile

Common Name: C. difficile

Characteristics:

Gram-positive

Anaerobic

Spore-forming

Motile

Pathogenicity and Virulence

Clostridioides (Clostridium) difficile is challenging to diagnose and treat as it forms spores and can persist asymptomatically within the gut. Some strains express multiple virulence factors, including adhesins and toxins (21).

Clostridioides difficile is a bacterial pathogen that causes a range of clinical diseases, from mild to moderate diarrhea to more severe cond…

References (Sources)

Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota
Fletcher et al. 2021
Clostridium difficile spore biology: sporulation, germination, and spore structural proteins
Paredes-Sabja et al. 2014 Trends Microbiol 22: 406-416
Review
Entry of spores into intestinal epithelial cells contributes to recurrence of Clostridioides difficile infection
Castro-Córdova et al. 2021 Nat Commun 12: 1140
The regulatory network controlling spore formation in Clostridium difficile
Saujet et al. 2014 FEMS Microbiol Lett 358: 1-10
Review
The role of toxin A and toxin B in Clostridium difﬁcile infection
Kuehne et al. 2010 Nature 467: 711-713
The role of toxin A and toxin B in the virulence of Clostridium difﬁcile
Carter et al. 2012 Trends Microbiol 20: 21-29
Trends in US burden of Clostridioides difficile infection and outcomes
Guh et al. 2020 N Engl J Med 382(14): 1320-1330

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Links

Clostridioides difficile (bacteria) - Wikipedia
https://doi.org/10.1007/978-3-319-74932-7_13