meRfi®-GM
Clostridioides (Clostridium) difficile
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Contents
General Information
- GeneBank Accessions: CP003939, CP010905
- Scientific Name: Clostridioides difficile
- Common Name: C. difficile
- Characteristics:
- Gram-positive
- Anaerobic
- Spore-forming
- Motile
Pathogenicity and Virulence
Clostridioides difficile is a bacterial pathogen that causes a range of clinical diseases, from mild to moderate diarrhea to more severe conditions such as pseudomembranous colitis and toxic megacolon (). The virulence of C. difficile is strain-dependent, with particularly virulent strains like the [Hypervirulent Clade 2](brain://KZitF6GUVUC14XOu8XP2nw/ClostridioidesDifficileFormerlyNamedClos…
References (Sources)
- Acquisition of Clostridium difficile by hospitalized patients: evidence for colonized new admissions as a source of infection
- Baseline human gut microbiota profile in healthy people and standard reporting template
- Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota
- Defining the roles of TcdA and TcdB in localized gastrointestinal disease, systemic organ damage, and the host response during Clostridium difficile infections
- The role of toxin A and toxin B in Clostridium difficile infection
- The role of toxin A and toxin B in the virulence of Clostridium difficile
- Third generation cephalosporins as a risk factor for Clostridium difficile-associated disease: a four-year survey in a general hospital