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Copanlisib

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Contents

Copanlisib is a class I inhibitor of PI3K with inhibitory activity predominantly against PI3Kalpha (half-maximal inhibitory concentrations (IC50 = 0.5 nM) and PI3Kdelta (IC50 = 0.7 nM) compared with PI3Kbeta (IC50 = 3.7 nM) and PI3Kgamma (IC50 = 6.4 nM) isoforms
Liu et al. 2013 Mol Cancer Ther 12: 2319-2330
Damodaran et al. 2022 J Clin Oncol 40: 1552-1561