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Mismatch repair (MMR) proteins are an essential part of the DNA mismatch repair pathway. This pathway plays a crucial role in correcting errors that occur during DNA replication, such as incorrect base pairings and small insertions or deletions
Defective DNA mismatch repair (dMMR) leads to high levels of microsatellite-instability (MSI-H) and insertions or deletions in coding regions, triggering the generation of tumor-specific frameshift peptides (FSPs).
see also:
[Colorectal Cancer (CRC) (Mismatch Repair Deficiency (MMR-d) / DNA Mismatch Repair / Microsatellite Instability (MSI))](brain://-yNcWH7dyUWSfQdoSwPsCQ/ColorectalCancerCrcMismatchRepairDe%EF%AC%81cien…