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Gut bacteria
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Human gut bacteria convert the secondary bile acid lithocholic acid with 3 alpha-hydroxysteroid dehydrogenase into 3-oxoLCA as well as the abundant gut metabolite isolithocholic acid (isoLCA))
Paik et al. 2022 Nature 603: 907
Gut bacteria play a crucial role in maintaining the health of the gastrointestinal tract. They:
- Secrete neurotransmitters
- Synthesize metabolites and endotoxins
- Regulate the permeability, structure, and function of the mucosa
These activities help normalize the functioning of the gastrointestinal tract. However, gut [dysbiosis](brain://ttq0yyI…
References (Sources)
- 1,520 Reference Genomes from Cultivated Human Gut Bacteria Enable Functional Microbiome Analyse
- Enteric dysbiosis associated with a mouse model of alcoholic liver disease
- Experimental evolution makes microbes more cooperative with their local host genotype
- How Changes in the Nutritional Landscape Shape Gut ImmunometabolismReview
- Is Gut Dysbiosis an Epicenter of Parkinson’s Disease?Review
- The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens