Neuroinflammation

Neuroinflammatory disorders may cause dysmotility and bowel dysfunction
Rosenberg & Rao 2021 iScience 24: 102863

Neuroinflammation can have various causes, including obesity and systemic inflammation. Inflammation can increase the permeability of the blood-brain barrier, allowing pro-inflammatory markers to enter the brain and contributing to neuroinflammation.
Olsthoorn et al. 2021 Front. Neurosci. 15: 761456

Definition: An inflammatory response or state in the brain that involves functional, morphological and energetic shifts in microglia and ‘reactive’ astrocytes , as well as macrophages that migrate into the brain from the periphery. It is a characteristic of neurodegenerative disorders and brain response to infectious agents or injury
Cunnane et al. 2020

In neuroinflammatory diseases, pathogenic immunity prevails, disrupting the structure and function of the CNS.
Benallegue et al. 2022 Immunol Rev 309:

T cells, in particular, play a crucial role in neuroinflammation.
Benallegue et al. 2022 Immunol Rev 309:

The inflamed CNS microenvironment affects T cells.
Benallegue et al. 2022 Immunol Rev 309:

Increasing Evidence Revealed that Peripheral Immune Cells Might Be Able to Infiltrate into Brain Tissues, Which Could Arouse Neuroinflammation and Aggravate Neurodegeneration
Zhang et al. 2021b

see also:
Cerebrovascular injury & Immune checkpoints
Cognition & Inflammation / Inflammatory Diseases
Protectins