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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Der p 1

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Der p 1 is a major allergen produced by the European house dust mite Dermatophagoides pteronyssinus. It is a cysteine protease enzyme that plays a significant role in dust mite allergies and asthma
Chapman & Platts-Mills 1980 J Immunol 125(2): 587-92
Kalsheker et al. 1996 Biochem Biophys Res Commun 221(1): 59-61
Gough et al. 1999 J Exp Med 190(12): 1897-9027

The Cysteine protease activity of Der p 1 led to an increase in gut epithelial permeability and the release of inflammatory mediators.
Tulic et al. 2016 Gut 65(5): 757-766

References (Sources)

Presence of commensal house dust mite allergen in human gastrointestinal tract: a potential contributor to intestinal barrier dysfunction
Tulic et al. 2016 Gut 65(5): 757-766
Purification and characterization of the major allergen from Dermatophagoides pteronyssinus-antigen P1
Chapman & Platts-Mills 1980 J Immunol 125(2): 587-92
The cysteine protease activity of the major dust mite allergen Der p 1 selectively enhances the immunoglobulin E antibody response
Gough et al. 1999 J Exp Med 190(12): 1897-9027
The house dust mite allergen Der p1 catalytically inactivates alpha 1-antitrypsin by specific reactive centre loop cleavage: a mechanism that promotes airway inflammation and asthma
Kalsheker et al. 1996 Biochem Biophys Res Commun 221(1): 59-61

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Der p 1

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