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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Immunomodulation & Short-Chain Fatty Acids (SCFAs)

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SCFA can regulate the production of cytokines, affect the class conversion of B cells, activate DC cells and macrophages, and affect the differentiation of memory T cells
Qiu et al. 2021a Front. Immunol.11: 612202

Short-Chain Fatty Acids (SCFAs) can modulate immune cell function by inhibiting histone deacetylases (HDACs)
Yang & Cong 2021 Cell Mol. Immunol. 18: 866-877

Short-Chain Fatty Acids (SCFAs), and in particular Butyrate / Butyric acid, also have critical [immunomodulatory functions](brain://WV9kDrzzFEe3dDVMQYEU-g/ButyrateImmunomodulatio…

References (Sources)

Butyrate and other short-chain fatty acids as modulators of immunity: what relevance for health?
Meijer et al. 2010 Current opinion in clinical nutrition and metabolic care 13:715–721
Review
Diet, metabolites, and “Western-lifestyle” inflammatory diseases
Thorburn et al. 2014 Immunity 40: 833-842
Exploring the Emerging Role of the Gut Microbiota and Tumor Microenvironment in Cancer Immunotherapy
Qiu et al. 2021a Front. Immunol.11: 612202
Review
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
Koh et al. 2016 Cell 165: 1332
Review
Gut microbiota, metabolites and host immunity
Rooks & Garrett 2016 Nature Rev. Immunology 16: 341
Review
The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
Brown et al. 2003 J. Biol. Chem. 278: 11312-11319
Understanding the Holobiont: How microbial metabolites affect human health and shape the immune system
Postler & Ghosh 2017
Review

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12/16/2025

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