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When activated by external conditions, the activities of Macrophages (CD68s) (M0) key glycolytic enzymes, including Hexokinase (HK), Phosphofructokinase (PFK) and Pyruvate kinase type M2 (PKM2), were correspondingly upregulated, increasing the rate of glycolysis, while inducing the polarization of M0 TAMs to [M1 TAMs](brain://Myuk2LyDhkKFuE1IaSvzug/M1…