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Helicobacter pylori infection

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Dysregulation of various cellular processes in the gastric epithelium and in different cells of the microenvironment is a hallmark of H. pylori infection
Lim et al. 2023 Trends in Cancer 9: 679

Myeloid-specific deletion of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine synthesis, promoted M1 immune response and therefore significantly enhanced gastritis during Helicobacter pylori infection, but alleviated DSS-induced colitis
Hardbower et al. 2017 Proc. Natl. Acad. Sci. USA 114: E751–E760
Singh et al. 2018 Cancer Res. 78: 4303-4315

Helicobacter pylori infection upregulates NF-kB to induce inflammation in the stomach (Ya…