Akkermansia muciniphila & Metabolic diseases / Metabolic disorders

Preclinical data

An experimental study investigating Akkermansia muciniphila BAA-835 in six-week-old male specific-pathogen-free (SPF)-grade C57BL/6 mice (n = 20) under normal chow diet vs normal chow diet without A. muciniphila showed that daily gavage for five weeks significantly reduced body weight gain, fat mass, and improved glucose tolerance and insulin sensitivity. The supplementation also decreased gene expression related to fatty acid synthesis and transport, alleviated endoplasmic reticulum stress, and reduced chronic low-grade inflammation. Metabolomics profiling indicated increased anti-inflammatory factors and decreased certain amino acids. The findings suggest that Akkermansia muciniphila BAA-835 supplementation can relieve met…