G-Protein Coupled Receptor 41 (GPR41) & Metabolic Functions

GPR41 are sensory receptors for nutrients to elicit glucose-stimulated insulin secretion from pancreatic β-cells [41]
Zhi et al. 2019 European Journal of Clinical Microbiology & Infectious Diseases 38: 1987-1998

GPR41 co-localized with L cells and activated by microbiota SCFA ligands promote the release of GLP-1 and PYY [42]
Zhi et al. 2019 European Journal of Clinical Microbiology & Infectious Diseases 38: 1987-1998

GPR41 receptors are present in human adipocytes and cells of the sympathetic nervous system [39]
Zhi et al. 2019 European Journal of Clinical Microbiology & Infectious Diseases 38: 1987-1998

In addition, sympathetic ganglia and intestinal neurons activate the GPR41 receptor in the intestine, improving sympathetic outflow and gut gluconeogenesis, increasing energy expenditure, and reducing hepatic glucose production [41].
Zhi et al. 2019 European Journal of Clinical Microbiology & Infectious Diseases 38: 1987-1998