meRfi®-GM
Farnesoid X receptor (FXR / NR1H4)
Welcome to meRfi-GM!
meRfi-GM provides you with up-to-date, evidence-based insights on the gut microbiota and related health topics.
Access our ever-expanding digital library and get personalized answers through our interactive AI chat platform.
Start your free trial and transform your understanding of the gut microbiota today!
Navigation
Contents
Dimer: NR1H/RXR
The Farnesoid X receptor (FXR / NR1H4) is a ligand-induced transcription factor and a member of the nuclear receptor (NR) superfamily.
- Identified in 1999 as a bile salt-activated transcription factor.
- Plays a crucial role in various physiological processes.
- Essential for regulating intestinal innate immunity and homeostasis.
Farnesoid X receptor (FXR / NR1H4) was identified as a cell surface receptor for bile salts and they co-expressed in the enteroendocrine L cells.
References:
see also:
[Metabolic Syndro…
References (Sources)
- Bile acid-induced negative feedback regulation of the human ileal bile acid transporter.
- Bile acids: natural ligands for an orphan nuclear receptor
- Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
- Identification of a bile acid-responsive element in the human ileal bile acidbinding protein gene. Involvement Of the farnesoid x receptor/9-cis-retinoic acid receptor heterodimer.
- Identification of a nuclear receptor for bile acids
- Interactions between bile salts, gut microbiota, and hepatic innate immunity
- The bile acid receptor FXR is a modulator of intestinal innate immunity