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Resident enteric bacteria are necessary for the development of spontaneous colitis and immune system activation in Interleukin-10 (IL-10) Deficient Mice
In IL-10-deficient mice, generated by gene targeting, lymphocyte development and antibody responses are normal, but most animals are growth retarded and anemic and suffer from chronic enterocolitis
Kuhn et al. 1993 Cell 75: 26…