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Dextran sulfate sodium (DSS) impairs the intestinal barrier, leading to the translocation of gut commensals to distal tissues, including the bone marrow (BM), and inducing a pro-inflammatory state in the host.
This translocation of microbiota induced epigenetic changes and promoted trained immunity (TI) in Bone marrow progenitors (BMPs). Among the bacteria identified in the BM, Enterococcus faecalis was found to activate immune cells in a Mincle-dependent manner. In line with this, [Macrophage-ind…