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Historically, high-density urban environments have housed only a fraction of the global population, with the majority residing in rural areas or small villages. However, in the last two decades, this trend has reversed. Currently, 55% of the world’s population lives in urban areas
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Urban diet, increased sanitation, and antibiotic exposure contribute to what has been termed “microbiota insufficiency syndrome” (“the loss of microbial taxa and associated [microbial] functions that have been part of our evolutionary past”)
This has also been linked to an increase in immune and metaboli…