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Tau is a microtubule-associated protein that is abnormally phosphorylated to make up the paired helical filaments of neurofibrillary tangles in Alzheimer's disease (AD) leading to microtubule disassembly and impairment of axonal transport.
Tau hyperphosphorylation contributes to the disassembly of microtubules, which leads to the impairment of neuronal and synaptic structures and the formation of nerve fiber tangles
The …