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Tau hyperphosphorylation
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Contents
Tau hyperphosphorylation contributes to the disassembly of microtubules, which leads to the impairment of neuronal and synaptic structures and the formation of nerve fiber tangles [3].
Zhang et al. 2021j
Tau is a microtubule-associated protein that is abnormally phosphorylated to make up the paired helical filaments of neurofibrillary tangles in AD (IM)
Naomi et al. 2022 Nutrients 14: 20 (IM)
The essential neuropathologic criteria for an AD diagnosis are extracellular amyloid-beta deposition and intracellular accumulation of hyperphosphorylated tau
Zhang et al. 2021j
The tau protein hypothesis is backed …