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SpeG belongs to the spermidine/spermine acetyltransferase (SSAT) family that plays important roles in regulating polyamine concentrations in bacteria
The homologs of SpeG are responsible for the production of N-acetylputrescine and diacetylspermidine in gram-negative pathogens.
Diminazene acts as an inhibitor of SpeG, leading to a reduction in bacterial proliferation. If the activity of SpeG is reduced, the bacterial membrane permeability is increased, which synerg…