Clostridium butyricum & Chemotherapy (CT) (to improve)

Clostridium butyricum has shown promising potential in improving outcomes for cancer patients undergoing chemotherapy, particularly in addressing some of the common side effects and enhancing treatment efficacy.

Reduction of Chemotherapy-Induced Nausea and Vomiting (CINV)

• A study on colorectal cancer mice showed that combining thalidomide and C. butyricum effectively reduced CINV by inhibiting neurotransmitters (e.g., 5-HT and tachykinin 1) and their receptors in the brain and colon.


• This combination also enhanced the anticancer effect of cisplatin by activating the caspase-3 apoptosis pathway

Zhao et al. 2023a Front Immunol. 14: 1220165

Gut Microbiota Modulation

C. butyricum has been found to positively influence the gut microbiome, which can be disrupted by chemotherapy:

• The probiotic increas…