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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

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Branched-Chain Amino Acids (BCAAs)

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Branched-Chain Amino Acids (BCAAs) circulate in plasma as free amino acids (AAs) and are absorbed by virtually all tissues using tissue-specific carriers (Gojda & Cahova 2021 Biomolecules 11: 1414). The primary BCAAs include leucine (Leu), isoleucine (Ile), and valine (Val) (Nie et al. 2018 Int. J. Mol. Sci. 19: 954).

Health Implications

BCAAs are known risk factors for several metabolic and cardiovascular conditions, including:

Insulin resistance

Hyperglycemia

[Hyperlipidemia](brain://PFmjDf…

References (Sources)

A new syndrome: progressive familial infantile cerebral dysfunction associated with an unusual urinary substance
Menkes et al. 1954 Pediatrics 14: 462-467
Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention
Liu et al. 2017 Nature Medicine 23: 859-868
Gut Microbiota as the Link between Elevated BCAA Serum Levels and Insulin Resistance
Gojda & Cahova 2021 Biomolecules 11: 1414
Review
Metabolic and Physiological Roles of Branched-Chain Amino Acids
Monirujjaman & Ferdouse 2014 Advances in Molecular Biology 2014: Article ID 364976
Review
Metabolite profiles and the risk of developing diabetes
Wang et al. 2011b Nat Med 17: 448-453
Milk and Health
Willett & Ludwig 2020
Review
Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
Mayers et al. 2016 Science 353: 1161-5

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