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Immunoglobulin G (IgG) antibodies are notable for their ability to deplete target cells, a process commonly known as antibody-dependent cellular cytotoxicity (ADCC). This ability to destroy target cells has established cytotoxic antibodies as a standard treatment for a variety of malignant, autoimmune, and infectious diseases. Despite this, the effectiveness of cytotoxic antibodies in therapeutic applications is frequently restricted, and existing optimization strategies have only slightly improved their therapeutic effectiveness.
Antibody binding to pathogen surfaces or infected cells also ‘‘flags’’ the cells as targets for innate immune cell-mediated killing, thereby promoting pathogen clearance.
Chi et al. 2024a…