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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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2′-Fucosyllactose (2’FL)

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Contents

2′-Fucosyllactose (2′-FL) is the most abundant component in human milk with a positive secretor status, i.e., those expressing fucosyltransferase 2. 2′-FL accounts for approximately 30% of the total Human Milk Oligosaccharides (HMOs) in human milk. The interaction between 2′-FL, host, and microbiota can be partially explained by the effects of bacterial metabolites derived from 2′-FL, which significantly impact intestinal homeostasis.
Zhang et al. 2023 Food Res Int 173: 113293

Studies indicate that 2′-fucosyllact…

References (Sources)

2’-Fucosyllactose (2’-FL) changes infants gut microbiota composition and their metabolism in a host-free human colonic model
Zhang et al. 2023 Food Res Int 173: 113293
2′-Fucosyllactose and 3-Fucosyllactose Alleviates Interleukin-6-Induced Barrier Dysfunction and Dextran Sodium Sulfate-Induced Colitis by Improving Intestinal Barrier Function and Modulating the Intestinal Microbiome
Kim et al. 2023 Nutrients 15: 1845
2′-Fucosyllactose and 3′-Sialyllactose Reduce Mortality in Neonatal Enteroaggregative Escherichia coli Infection by Improving the Construction of Intestinal Mucosal Immunity
Liu et al. 2024 J Agric Food Chem 72(47): 26165-26177
Cognitive and behavioral benefits of 2′-fucosyllactose in growing mice: the roles of 5-hydroxytryptophan and gut microbiota
Zhu et al. 2025 Microbiome 13: 97
Fucose as a cleavage product of 2’-fucosyllactose does not cross the blood-brain barrier in mice
Rudloff et al. 2021 Mol Nutr Food Res 65(16): 2100045
Human milk oligosaccharides: a critical review on structure, preparation, their potential as a food bioactive component, and future perspectives
Zhu et al. 2023 J Agric Food Chem 71(43): 15908-25
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2'-Fucosyllactose - Wikipedia