meRfi®-GM
Microbiota-Gut-Liver-Axis (GLA)
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The gut and liver reciprocally communicate to control gut homeostasis and tissue repair during health and diseases. Kim et al. demonstrate that liver-derived soluble factor pigment epithelium-derived factor (PEDF) restrains intestinal stem cell (ISC) expansion, suggesting that the gut-liver axis calibrates ISC fitness for intestinal homeostasis.
The Microbiota-gut-liver-axis is a bidirectional, anatomical, and functional relationship between the gastrointestinal system and the liver, primarily through a portal circulation.
Russo et al. 2022 World J Hepatol 14(2)…
References (Sources)
- Clinical Aspects of Gut Microbiota in Hepatocellular Carcinoma Management
- Emulating the gut-liver axis: Dissecting the microbiome's effect on drug metabolism using multiorgan-on-chip models
- Gut-liver axis at the frontier of host-microbial interactions
- Gut-Liver Axis, Gut Microbiota, and Its Modulation in the Management of Liver Diseases: A Review of the Referencese
- Gut–liver axis: the impact of gut microbiota on non alcoholic fatty liver disease
- The liver at the nexus of host-microbial interactions
- The microbiome and autoimmunity: a paradigm from the gut-liver axis