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Especially the newly developed humanized mice resemble humans in many aspects, including genetic, immunological, and microbiome factors
Significant advances in our understanding of the in vivo functions of human cells and tissues and the human immune system have resulted from the development of 'humanized' mouse strains that are based on severely immunodeficient mice with mutations in the interleukin-2 receptor common gamma-chain locus.
These mouse strains support the engraftment of a functional human immune system and permit detailed analyses of human immune biology, development and functions.
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