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Gut microbiota / Evidence-based microbiome knowledge (incl. AI chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Live bacterial therapeutics (LBTs)

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Contents

LBTs might be native strains from human-associated or environmental microbiota, or strains that have been engineered (Engineered Live Bacterial Therapeutics) to express therapeutic molecules, target specific pathogens, or deliver drugs directly to a disease site

Programs to manipulate the microbiome are

Adding beneficial strains

Removing harmful microbes

Rebalancing the existing population with drugs

McChalicher & Auniņš 2022 Current Opinion in Biotechnology 78: 10280

Key considerations for bacterial LBPs:

Product quality

Manufacturing

Quality control

Regulation

McChalicher & Auniņš 2022 Current Opinion in Biotechnology 78: 10280

Formulations of [next-generation live biotherapeutics](brain://kmHc674OLU-wccu502JAIQ/NextGen…

References (Sources)

Drugging the microbiome and bacterial live biotherapeutic consortium production
McChalicher & Auniņš 2022 Current Opinion in Biotechnology 78: 10280
Emerging strategies for engineering Escherichia coli Nissle 1917-based therapeutics
Lynch et al. 2022 Trends in Pharmacological Sciences 43(9): 772
Review
Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models
Hwang et al. 2017 Nature Commun. 8: 15028
Genetically engineered phages: a review of advances over the last decade
Pires et al. 2016 Microbiol Mol Biol Rev 80: 523-543
Review
Microbiome engineering: Current applications and its future
Foo et al. 2017
Review
Population-level analysis of gut microbiome variation
Falony et al. 2016 Science 352: 560-564
Quinones are growth factors for the human gut microbiota
Fenn et al. 2017 Microbiome 5: 161

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