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Intratumor bacteria may be responsible for a clinically significant portion of gemcitabine metabolism
We hypothesized that intratumor bacteria metabolize a clinically meaningful fraction of administered gemcitabine. Based on this hypothesis, antibacterial therapy that reduces the population of long isoform of the bacterial enzyme Cytidine deaminase (CDDL)-expressing bacteria was expected to increase the effective dose of gemcitabine .
Antibacterial therapy that reduces the population of long isoform of the bacterial enzyme cytidine deaminase (CDDL)-expressing bacteria was expected to increase the rate of gemcitabine-associated toxicity
Geller et al. recently …