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Glioblastoma multiforme (GBM) / Glioblastoma is the the most common primary brain tumor in adults with a poor prognosis of 14.6 months and few treatment advancements over the last 10 years making it one of the most challenging to treat, even with extensive research efforts and various anticancer therapies available. Onset of disease is followed by a uniformly lethal prognosis and dismal overall survival (1, 2, 3).
The reason Glioblastoma multiforme (GBM) / Glioblastoma responds poorly to treatments is due to its unique characteristics. Notably, there is a scarcity of highly cytotoxic effector cells within the tumor microenvironment (5).
Glioblastoma multiforme (GBM) / Glioblastoma-associated receptors: …