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Cytolethal distending toxin (CDT)
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Cytolethal distending toxin (CDT) is produced by several Epsilonproteobacteria and Gammaproteobacteria. This bacterial toxin can directly damage DNA in mammalian cells
Cytolethal distending toxin (CDT) is a type of genotoxin that originates from bacteria. It is produced by different species, including Campylobacter, Escherichia, Helicobacter, and [Salmonella](brain://6k12r5Oz…
References (Sources)
- A bacterial toxin that controls cell cycle progression as a deoxyribonuclease I-like protein
- Campylobacter jejuni-derived cytolethal distending toxin promotes colorectal cancer metastasis
- Co-occurrence of anaerobic bacteria in colorectal carcinomas
- Gut microbiome compositional and functional differences between tumor and non-tumor adjacent tissues from cohorts from the US and Spain
- Gut mucosal microbiome across stages of colorectal carcinogenesis
- The biology of the cytolethal distending toxins
- The cytolethal distending toxin effects on Mammalian cells: a DNA damage perspective