Adiposity / Obesity & Leptin

In adiposity / obesity , a decreased sensitivity to leptin occurs (similar to insulin resistance in type 2 diabetes), resulting in an inability to detect satiety despite high energy stores and high levels of leptin

Weight loss was not significant in all the participants, although it was significant in women when analyzing both sexes separately (Sanchez et al. 2014 Br. J. Nutr. 111: 1507-1519), and that it was associated with a significant reduction in circulating leptin level, mainly in women
Santos-Marcos et al. 2019 Journal of Nutritional Biochemistry 70: 1-27

Increasing acetate and propionate in the peripheral circulation stimulates leptin release from adipocytes via activation of FFAR2. Leptin inhibits NPY / AgRP neurons and activates POMC / CART neurons. Acetate can cross the bloodbrain barrier and increase POMC and reduce AgRP expression
Chambers et al. 2015a Proc Nutr Soc 74: 328-36

Leptin is thought to play an essential role in obesity-related gastrointestinal malignancies because of its role in angiogenesis, apoptosis, cell proliferation, and cell migration
Howard et al. 2010 Obes Rev. 11: 863-74

Leptin is also associated with insulin resistance and central obesity
Pais et al. 2009 World J Gastroenterol 15: 5141-5148

Leptin-deficient mice develop obesity, insulin resistance, dyslipidemia and fatty livers (hepatic steatosis)
Campfield et al. 1996 Horm Metab Res 28: 619-632

see also:
Adiposity / Obesity & Cancer / Tumors
Adiposity / Obesity & Growth/differentiation factor 15 (GDF15)
Leptin & PI3K Signal transduction pathway