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Several immune strategies have been investigated in TNBC, including co-inhibitory molecules beyond PD1-PD-L1 axis, co-stimulatory checkpoints, cancer vaccines, adoptive cell transfer, combination therapies, as well as different routes of administration. Most of approaches showed signs of anti-cancer activity and a good safety profile in early-phase clinical trials. Since Cancer Immunotherapy / Immuno-Oncology provided benefit only to a small subgroup of Breast Cancer / Mammacarcinoma (TNBC) patients so far, identifying predictive biomarkers is a priority to refine patient-selection. Data from ongoing clinical trials, with the grad…